I, too, am completely confused by Clark's reaction to the kryptonite. I assume it effected him, because he's ... well, Clark, and Lois noticed he looked wan later, but if so he did a miraculous job of covering considering that he would have no way of knowing it would impact him.
I absolutely loved Clark in this chapter - all of his worldliness comes through in his exchanges with Luther and Mrs. Cox and Lois, in her new found appreciation for Clark, just rolls with it rather than rolling her eyes and wondering how a hack-from-Nowheresville got to know all this. I guess this means I loved Lois in this chapter, too.