Oh dearie me! Is Lois going back into depression.. If she does, I just hope Clark realizes that, and not just wallow in his misery..
Well technically she's been in depression since Chris' birth. In one of the last chapters, Lois mentioned that she should be mindful of certain triggers to her depression. Sam's health or death may severely worsen it.
But before Clark can wrap his mind around the idea that he is going to be with Lois, he will have to redefine himself. He will have to say goodbye to Clark-who-promised-the-Heavens-that-he-would-always-be-faithful-to-Lana and accept that he is in fact Clark-who-has-already-been unfaithful-to-Lana-and-fathered-a-child-with-Lois. And he will have to embrace himself as Clark-who-loves-Lois.
In this story, I've always thought that although Clark signed the marriage certificate with Lois, he's been mentally married and committed to Lana. It is this commitment that makes him constantly wonder whether Lana will take him back after the 5-year mark. In his head, Clark believes he is being faithful to Lana (even if the circumstances are a bit unusual), so it is this behaviour that keeps him going.
Lois said it best that she only wants Clark to kiss her if he wants to kiss her. In other words, she doesn't want to be Lana's substitute. I agree with this sentiment. For the bond to break between Clark and Lana, two things could happen: (1) Lana could die, Clark would grieve, and they maybe open his eyes to what's been in front of him this whole time; or (2) Lana and Clark need a falling out. This falling out could be related to him being an alien and her not approving, or it could be that Lana told the media about Clark not being Chris' biological father.
It maybe just me, but I can't see Clark and Lois building a solid relationship foundation without dealing with the third wheel of their marriage, Lana.