Corrina knows this already but I was just thinking about what's going to happen to everyone (and note, this is my speculation and totally *not* something that Corrina says):

Martha will be happy with Evan in Smallville. They'll raise the kids with lots of love.

Abi will learn how to knit. (Martha will teach her.)

After a year or so in Smallville, Layla will go to Metropolis to pursue her fashion designing career. (She might actually live in Sam's house while she goes to school in Metropolis, giving her a place to stay and giving Lois and Sam a tenant so that the house isn't empty.)

Layla be wildly successful as a fashion designer. In fact, whenever Phoebe Menzies goes out to an event (as wife of the executive director of the Superman Foundation, she and her husband will be attending a lot of events), she will wear Layla Shadbolt couture.

Eric Menzies will run the Superman Foundation and get it on a good footing. He'll feel much happier now that he's building up good karma points. He'll take frequent vacations with Phoebe and their marriage will gain new life.

Longford will remain happily retired. He'll cut out Daily Planet articles about Superman and paste them in a scrapbook.

Dan Scardino will become a career bureaucrat.

Ruby Rhodes will fail as a waitress.

Clark Kent, of course, will become an award-winning reporter at the Daily Planet.

And Lois? Well, who knows? Canon says that she becomes a reporter, too, but this isn't the canon world. And Lois is always surprising!