You know, I was thinking about this tonight, and I love how Lana and Chad came together, and Lois and Lana made their peace as well. (Of course, there might be some trouble convincing Lois that he WASN'T talking to her in order to get back together with her.)
But once that is settled, and Lois understands Clark really DOES love her and is not staying with her to "settle," (I don't know how long that will take), I can easily see both couples getting along well.
I can even picture them double-dating when their both in Smallville. That would be sweet, and it really shows how far they've come, and how much all of them have grown up.
